appetite drug

Truthful Hoodia vendors could forever provide the credential that their items are genuine. Or a producer might ignore to place the

---

---

Cyproheptadine (pronounced /ˌsaɪproʊˈhɛptəˌdin/ ; usually as cyproheptadine hydrochloride , trade name Periactin ) is an antihistaminic and antiserotonergic agent. It acts as a 5-HT ₂ receptor antagonist and also blocks calcium channels.

Uses

Cyproheptadine is used in the treatment of allergies (specifically hay fever) and is also used to stimulate appetite in underweight people (e.g. anorexia nervosa).

Cyproheptadine has shown effectiveness in the treatment of nightmares including nightmares related to post traumatic stress disorder.

Cyproheptadine has been used in the management of moderate to severe cases of serotonin syndrome (a complex of symptoms associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors or stimulants), and in the disease carcinoid in which serotonin is overproduced by tumor cells.

Cyproheptadine can also be used as a preventative measure against migraine in children and adolescents.

Cyproheptadine can relieve SSRI-induced sexual dysfunction and drug-induced hyperhydrosis (excess sweating).

Adverse effects

While not specifically used as a sedative, cyproheptadine causes drowsiness, as is common with first-generation antihistamines.

Digestive system: epigastric distress (dysphagia), nausea, vomiting, (it is noted that these side effects are much more common in people with neuromuscular disorders)

Cyproheptadine can also cause over-sleeping (10 Hours) in children and adolescents.

Research

Cyproheptadine has been shown to improve quality of sleep in sleep-deprived rats.

Cyproheptadine interacts with several other medications such as MAOIs (monoamine oxidase inhibitors) and potassium salts and can cause adverse reactions. Anti-cholinergic medications such as Cyproheptadine, when used in conjunction with oral potassium salts, can cause slowing of GI transit and increases the local exposure to high potassium concentrations. High potassium concentrations may lead to GI tract ulceration or stenosis.

Veterinary use

Cyproheptadine is used in cats as an appetite stimulant and as an adjunct in the treatment of asthma. Possible adverse effects include excitement and aggressive behavior.

The elimination half-life of cyproheptadine in cats is 12 hours.

References

1. ^ Lowe DA, Matthews EK, Richardson BP (November 1981). "The calcium antagonistic effects of cyproheptadine on contraction, membrane electrical events and calcium influx in the guinea-pig taenia coli". British Journal of Pharmacology 74 (3): 651–63. PMID 6271323.  
2. ^ MedlinePlus Drug Information: Cyproheptadine
3. ^ Rijnders, R. J.P. (2000). "Cyproheptadine for Posttraumatic Nightmares". American Journal of Psychiatry 157 : 1524-a. doi: 10.1176/appi.ajp.157.9.1524-a . PMID 10964879 . http://ajp.psychiatryonline.org/cgi/content/full/157/9/1524-a .  
4. ^ Gupta, S; Popli, A; Bathurst, E; Hennig, L; Droney, T; Keller, P (May 1998). "Efficacy of cyproheptadine for nightmares associated with posttraumatic stress disorder.". Comprehensive psychiatry 39 (3): 160–4. ISSN 0010-440X. PMID 9606583.  
5. ^ Mills KC (October 1995). "Serotonin syndrome". American Family Physician 52 (5): 1475–82. PMID 7572570.  
6. ^ Gillman PK (1999). "The serotonin syndrome and its treatment". Journal of Psychopharmacology (Oxford, England) 13 (1): 100–9. PMID 10221364.  
7. ^ Hall M, Buckley N (2003). "Serotonin syndrome". Australian Prescriber 26 (3): 62–3 . http://www.australianprescriber.com/magazine/26/3/62/3 .  
8. ^ Berry EM, Maunder C, Wilson M (January 1974). "Carcinoid myopathy and treatment with cyproheptadine (Periactin)". Gut 15 (1): 34–8. doi: 10.1136/gut.15.1.34 . PMID 4274414. PMC: 1412931 . http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=4274414 .  
9. ^ Moertel, Charles G. (1991). "A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome". Cancer 67 : 33. doi: 10.1002/1097-0142(19910101)67:1<33::AID-CNCR2820670107>3.0.CO;2-E . http://www3.interscience.wiley.com/journal/112674381/abstract .  
10. ^ Wendy G Mitchell et al. (2006). "Childhood Migraine Variants".
11. ^ UVA Neurogram: Treatment of Pediatric Migraine
12. ^ Netdoctor: Periactin
13. ^ Migraines in Children and Adolescents
14. ^ Klimek A (1979). "Cyproheptadine (Peritol) in the treatment of migraine and related headache". Ther Hung 27 (2): 93–4. PMID 494146.  
15. ^ Keller Ashton A, Hamer R, Rosen RC (1997). "Serotonin reuptake inhibitor-induced sexual dysfunction and its tre